Research Interests
Dr.
Calhoun studies mechanisms of asthma, with a special emphasis on steroid
resistance and severe asthma. A focus of his research is dysfunction
of the glucocorticoid receptor [GR] in asthma, from both pre- and post-translational
mechanisms. In addition, he has interest in cytokine networking,
and the regulation of inflammation and its consequences by anti-inflammatory
cytokines such as IL-10. Using a murine model, Dr's Calhoun and
Ameredes have demonstrated important interactions among inflammation,
cytokine regulation, and gaseous signaling molecules. In addition,
Dr Calhoun heads the UTMB site for the NIH-funded Asthma Clinical Research
Network, a collaborative network of 8 funded centers nationwide that
focuses on the key questions of asthma management.
Selected Publications
- Erdely A, Kepka-Lenhart D, Clark M, Zeidler-Erdely P, Poljakovic M, Calhoun
W.J., Morris SM Jr. Inhibition of phosphodiesterase 4 amplifies
cytokine-dependent induction of arginase in macrophages. Am J Physiol
Lung Cell Mol Physiol. 290(3): L534-9, 2006. Epub Oct. 2005.
- Zeidler-Erdely, P.C., Calhoun, W.J., Ameredes, B.T., Clark,
M.P., Deye, G.J., Baron, P., Jones, W., Blake, T., Castranova, V. RE: In
vitro cytotoxicity of Manville Code 100 glass fibers: effect of fiber
length on human alveolar macrophages. Particle and Fiber Toxicology 28:
3:5, 2006.
- Ameredes, B.T., Calhoun, W.J. Rebuttal by Drs. Ameredes and
Calhoun. Am J Respir Crit Care Med. 174(9):972-4, 2006.
- Ameredes, B.T., Calhoun, W.J. (R)-Albuterol for Asthma: Pro
[a.k.a. (S)-Albuterol for Asthma: Con]. Am J Respir Crit Care Med. 174(9):965-9,
2006.
- Ogawa,Y., Calhoun, W.J. The role of leukotrienes in airway inflammation. J
Allergy Clin Immunol. 118(4):789-98, 2006.
- Moore, W.C., Bleecker, E.R., Curran-Everett, D., Erzurum, S.C., Ameredes,
B.T., Bacharier, L., Calhoun, W.J., Castro, M., Chung, K.F., Clark,
M.P., Dweik, R.A., Fitzpatrick, A.M., Gaston, B., Hew, M. Hussain, I.,
Jarjour, N.N., Israel, E., Levy, B.D., Murphy, J.R., Peters, S.P., Teague,
W.G., Meyers, D.A., Busse, W.W., Wenzel, S.E. Characterization of the
Severe Asthma Phenotype by the NHLBI’s Severe Asthma Research Program. J
Allergy Clin Immunol. 119(2): 405-13, Feb, 2007.
- Atanasov, S.T., Calhoun, W.J. The Relationship between Sleep
and Asthma. J Sleep Medicine Clinics. 2: 9-18, 2007.
- Wenzel, S.E., Busse W., Calhoun, W.J., Panettiere Jr., R., Peters-Golden,
M., Dube L., Walton-Bowen, K., Russel H., Harris J. The Safety and Efficacy
of Zileuton Controlled-Release (CR) Tablets as Adjunctive Therapy to
Usual Care (UC) in the Treatment of Moderate Persistent Asthma: A 6-Month
Randomized Controlled Study. J Asthma. 44(4): 305-310, 2007
- Baumgartner, R.A., Hanania, N.A.Calhoun, W.J., Sahn,
S.A., Sciarappa, K., Hanrahan, J.P. Nebulized Arformoterol in Patients with COPD: A
Twelve Week, Multi-center, Randomized, Double-Blind, Double-Dummy, Placebo
and Active-Controlled Trial. Clin Therapeutics. 29(2): 261-278,
2007
- Wenzel, S.E., Balzar, S., Ampleford, E., Hawkins, G.A., Busse, W.W., Calhoun,
W.J., Castro, M., Chung, F., Erzurum, S., Gaston, B., Israel, E.,
Teague, W.G., Everett, D., Meyers, D.A, Bleecker, E.R. IL-4Ra Mutations
are associated with Asthma Exacerbations and Tissue Mast Cell/IgE Expression. Am
J Respir Crit Care Med. 175: 570-576, 2007
- Brasier, A.R, Victor, S., Boetticher, G.D., Ju, H, Lee, C., Bleecker,
E.R., Castro, M., Busse, W.W., Calhoun W.J. Molecular Phenotyping
of Severe Asthma Using Pattern Recognition of Bronchoalveolar Lavage-Derived
Cytokines. 2007, J. Allergy Clin. Immun., in press.