Mark Emmett, PhD

Professor, Department of Biochemistry and Molecular Biology,
Sealy Center for Molecular Medicine

Phone: (409) 747-1943
Email: mremmett@utmb.edu

Mark Emmett, PhD

Research Interests

Dr. Emmett's current research specializes in identification of novel therapeutic targets and biomarkers in oncology (esp. neuro-oncology). Dr. Emmett utilizes high-resolution mass spectrometry (FT-ICR MS) and develops novel chromatographic and MS based methodology for high sensitivity endogenous biomolecule analysis. Dr. Emmett has established a multi-disciplinary research group enabling a systems biological approach integrating geneomics, transcriptomics, proteomics, glycomics, lipidomics, metabolomics, phenotypic responses with computational mathematical data analysis to the study of cancer focusing on the identification of novel biomarkers and therapeutic targets.

Recent Publications

  1. Proteomic Investigation of Glioblastoma Cell Lines Treated with Wild-Type p53 and Cytotoxic Chemotherapy Demonstrates an Association between Galectin-1 and p53 Expression, Maja Puchades, Carol L. Nilsson, Mark R. Emmett, Kenneth D. Aldape, Yongjie Ji, Frederick F. Land, Ta-Jen Liu, and Charles A. Conrad, Journal of Proteome Research, 2007, 6: 869-875.

  2. Method for Lipidomic Analysis: p53 Expression Modulation of Sulfatide, Ganglioside and Phospholipid Composition of U87 MG Glioblastoma Cells, Huan He, Charles A. Conrad, Carol L. Nilsson, Yongjie Ji, Tanner M. Schaub, Alan G. Marshall and Mark R. Emmett, Analytical Chemistry, 2007, 79: 8423-8430.

  3. KIT Kinase Mutants Show Unique Mechanisms of Drug Resistance to Imatinib and Sunitinib in Gastrointestinal Stromal Tumor Patients, Gajiwala, K. S.; Wu, J. C.; Christensen, J.; Deshmukh, G. D.; Diehl, W.; DiNitto, J. P.; English, J. M.; Greig, M.; He, Y.-A.; Jacques, S. L.; Lunney, E. A.; McTigue, M; Molina, D.; Quenzer, T. A.; Wells, P. A.; Yu, X.; Zhang, Y.; Zou, A.; Emmett, M. R.; Marshall, A. G.; Zhang, H.-M.; Demetri, G. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 1542-1547.

  4. Polar lipid remodeling and increased sulfatide expression are associated with the glioma therapeutic candidates, wild type p53 elevation and the topoisomerase-1 inhibitor, Irinotecan, Huan He, Carol L. Nilsson, Mark R. Emmett, Yongjie Ji, Alan G. Marshall, Roger A. Kroes, Joseph R. Moskal, Howard Colman, Frederick F. Lang, and Charles A. Conrad, Glycoconjugates. 2010, 27(1): 27-38.

  5. Glycomic and transcriptomic response of GSC-11 glioblastoma stem cells to STAT-3 phosphorylation inhibition and serum-induced differentiation, Huan He, Carol L. Nilsson, Mark R. Emmett, Alan G. Marshall, Roger A. Kroes, Joseph R. Moskal, Yongjie Ji, Howard Colman, Waldemar Priebe, Frederick F. Lang, and Charles A. Conrad, J. Proteomics Research, 2010, 9: 2098-2108.

  6. Overexpression of ST6GalNAcV, a ganglioside-specific a2,6 sialyltransferase, inhibits glioma invasivity. Roger A. Kroes, Huan He, Mark R. Emmett, Carol L. Nilsson, Alan G. Marshall, and Joseph R. Moskal, Proceedings of the National Academy of Sciences, 2010, 107 (28): 12646-12651.

  7. Liquid Chromatography Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Characterization of N-Linked Glycans and Glycopeptides, Xu Wang, Mark R. Emmett, and Alan G. Marshall, Analytical Chemistry, 2010, 82, 6542-6548.

  8. New Reagents for Enhanced Liquid Chromatographic Separation and Charging of Intact Protein Ions for Electrospray Ionization Mass Spectrometry, Santosh G. Valeja, Jeremiah D. Tipton, Mark R. Emmett and Alan G. Marshall, Analytical Chemistry, 2010, 82, 7515-7519.

  9. Computing H/D-Exchange rates of single residues from data of proteolytic fragments, Ernst Althaus, Stefan Canzar, Carsten Ehrler, Mark R. Emmett, Andres Karrenbauer, Alan G. Marshall, Anke Meyer-Baese, Jeremiah D. Tipton and Huimin Zhang, BMC Bioinformatics, 2010, 11: 424-436.

  10. Determining and interpreting correlations in lipidomic networks found in glioblastoma cells, Robert Gorke, Anke Meyer-Base, Dorothea Wagner, Huan He, Mark R. Emmett, Charles A. Conrad, BMC Systems Biology, 2010, 4: 126-139. http:www.biomedcentral.com/1752-0509/4/126.

  11. Complexation and Calcium-Induced Conformational Changes in the Cardiac Troponin Complex Monitored by Hydrogen/Deuterium Exchange and FT-ICR Mass Spectrometry, George M. Bou-Assaf, Jean E. Chamoun, Mark R. Emmett, Piotr G. Fajer, and Alan G. Marshall, 2010, International Journal of Mass Spectrometry, 2010, 302: 116-124.

  12. High Mass Accuracy and Resolution Facilitate Identification of Glycosphingolipids and Phospholipids, Huan He, Mark R. Emmett, Carol L. Nilsson, Charles A. Conrad and Alan G. Marshall, 2011, International Journal of Mass Spectrometry, 305: 116-119.

  13. Characterization of the Phosphoproteome in Androgen-Repressed Human Prostate Cancer Cells by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Xu Wang, Paul A. Stewart, Qiang Cao, Qing-Xiang Amy Sang, Leland W.K. Chung, Mark R. Emmett and Alan G. Marshall, Journal of Proteome Research, 2011, 10: 3920-3928.

  14. Epitope Mapping of a 95 kDa Antigen in Complex with Antibody by Solution-Phase Amide Backbone Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Analytical Chemistry, 2011, 83: 7129-7136.

  15. Novel Polar Aprotic Modifiers Enhance Chromatographic Separation, Increase Throughput, and Reduce Back-Exchange for Protein Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Santosh G. Valeja1, Mark R. Emmett1,2,*, and Alan G. Marshall, 2011, Journal of American Society for Mass Spectrometry, 2012, 23: 6634-6637.637

  16. Protein Expression in Glioma-Derived Stem-Like Cells correlated to Gene Expression Data and Patient Outcomes, Nilsson, Carol L;Sulman, Erik; Liu, Huiling; Wild, Christopher; Lichti, Cheryl F.; Emmett, Mark R.; Lang, Frederick F.; Conrad, Charles A., Neuro-Oncology, 2012, 14: 96-97

  17. D-Glucose and D-mannose-based metabolic probes. Part 3. Synthesis of specifically deuterated D-glucose, D-mannose and 2-deoxy-D-glucose. Izabela Fokt, Stanislaw Skora, Charles Conrad, Timothy Madden, Mark Emmett, and Waldemar Priebe, Carbohydrate Research, 2013, 368: 111-119

  18. Integrative Biological Analysis For Neuropsychopharmacology, Mark R. Emmett, Roger A. Kroes, Joseph R. Moskal, Charles A. Conrad, Waldemar Priebe, Fernanda Laezza, Anke Meyer-Baese and Carol L. Nilsson, Neuropsychopharmacology REVIEWS, 2014, 39: 5-23.