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Bing Tian, PhD

Assistant Professor, Department of Internal Medicine
Sealy Center of Molecular Medicine

Phone: (409) 772-7571
Email:  bitian@utmb.edu

Bing Tian, PhD

Research Interests

My research interests mainly focus on signaling mechanism of innate immune response during airway inflammation using molecular biology, cell biology, system biology, biochemical, and dynamic imaging approaches. One of my major concentrations is to understand signaling pathways controlling the "master" regulator of inflammation known as nuclear factor-kB (NF-kB) signaling networks in airway epithelial cells in response to viral infection, cytokine stimulation, and double stranded RNA exposure. Most recently, we established a model of stable type II epithelial-mesenchymal transition (EMT) induced by chronic TGFb stimulation of telomerase-immortalized primary human small airway epithelial cells (hSAECs) and we are using this model to actively explore the pathogenesis and therapeutic interventions of severe asthma associated with fibrosis.

Peer Reviewed Manuscripts

  • Tian B, Zhang YH, Luxon BA, Garofalo RP, Casola A, Sinha M, Brasier AR, Identification of NF-kappa B-dependent gene networks in respiratory syncytial virus-infected cells, J Virol 76 (13): 6800-6814 July 2002

  • Tian B, Nowak D., and Brasier AR. A TNF Induced Gene Expression Program Under Oscillatory NF-kB Control.  BMC Genomics, 2005; 6:137.  PMCID: PMC1262712.

  • Tian B, Nowak D, Jamaluddin M, Wang S, and Brasier AR.  Identification Of Direct Genomic Targets Downstream Of The NF-kB Transcription Factor Mediating TNF Signaling.  J.Biol. Chem., 2005; 280:17435-17448. PMID: 15722553.

  • Nowak DE, Tian B, Jamaluddin M, Boldogh I, Vergara LA, Choudhary S, and Brasier AR.  Rel A Ser276 Phosphorylation is required for activation of a subset of NF-kB Dependent Genes by Recruiting Cdk-9/Cyclin T1 Complexes.  Mol Cell Biol,  28: 3623-3638, 2008.  PMC2423290

  • Jamaluddin M, Tian B, Boldogh I, Garofalo RP and Brasier AR  Respiratory Syncyctial Virus Infection Induces A ROS-MSK1-Phospho-Ser-276 RelA Pathway Required For Cytokine Expression. J Virol, 83: 10605-10615, 2009.  PMCID: PMC2753134.

  • Choudhary S., Fang L, Tian B, Wu Z, Rosenblatt KP, and Brasier AR.  High Throughput siRNA Screening of the Human Kinome Identifies Novel Kinases Controlling the Canonical NF-kB Activation Pathway.  J. Biol. Chem,  286: 37187-95, 2011.  PMCID: 3199466.

  • Brasier AR, Tian B, Jamaluddin M, Kalita MK, Garofalo RP, and Lu M.   RelA Ser 276 Phosphorylation-Coupled Lys 310 Acetylation Controls Transcriptional Elongation Of Inflammatory Cytokines In RSV Infection.  J Virol, 85: 11752-11769, 2011.  PMCID:PMC3209292.

  • Kalita M, Sargysan K, Tian B, Paulucci A, Najm H, DeBusschere B, and Brasier AR.  Sources of Cell-to-cell Variability in Canonical Nuclear Factor-kB (NF-kB) Signaling Pathway Inferred from Single Cell Dynamic Images.  J. Biol. Chem, 286:37741-57, 2011. PMCID: PMC3199517.

  • Tian B, Zhao Y., Kalita M., Edeh M, Paessler S, Casola A. Teng MF, Garofalo RP and Brasier AR.  CDK9-dependent transcriptional elongation in the innate ISG response to RSV infection in airway epithelial cells. J Virol. 2013 Jun; 87(12):7075-92.

  • Kalita M, Tian B, Gao B, Choudhary S, Wood TG, Carmical JR, Boldogh I, Mitra S, Minna JD, Brasier AR. Systems approaches to modeling chronic mucosal inflammation. Biomed Res Int. 2013

  • Bertolusso R, Tian B, Zhao Y, Vergara L, Sabree A, Iwanaszko M, Lipniacki T, Brasier AR, and Kimmel M. Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise. PLoS One. 2014 Apr 7; 9(4): e93396

  • Li X, Zhao Y, Tian B, Jamaluddin M, Mitra A, Yang J, Rowicka M, Brasier AR, Kudlicki A. Probabilistic Integrative Approach to Inferring the Modulation of NF-kB/RelA Dependent Transcription J Biol Chem. 2014 Apr 25;289(17):11927-44

Reviews

  • Tian B and Brasier AR. Identification of an NF-kB dependent gene network. Recent Prog Horm Res, Edited by A. Means. 58:95-130, 2003

  • Nowak DE. Tian B, Brasier AR.  Novel Two-Step Cross-linking method for Identification of NF-kB Gene Network by Chromatin Immunoprecipitation.  Biotechniques, 39: 715-725, 2005.  PMID: 16315372.

     
  • Tian B and Brasier AR (2006). The Nuclear Factor-kB (NF-kB) Gene Regulatory Network. Microarrays and Transcription Networks, Edited by Frances Shannon and Sudha Rhao. © 2005, Landes Bioscience, Eurekah.com.
  • Brasier AR, Liu P, Tian B. and Choudhary.  Signaling pathways in the host cell response to RSV infection.  In Host Gene Responses to RNA Viral Infection, Edited by Decheng Yang, World Scientific Publishing, 2008.

  • Tian B, Yang J, and Brasier AR.  Two-step Crosslinking for Analysis of Protein-Chromatin Interactions.  Methods in Molecular Biology, Transcriptional Regulation, Methods and Protocols.  A. Vercura, Editor.  2012; 809:105-20