Title
T-cell and Soluble Co-inhibitory Receptor
Expression in Patients With Visceral Leishmaniasis Are Markers of Treatment Response and Clinical Outcome
Authors
Muluneh Ademe, Yaneth Osorio, Helina Fikre, Desalegn Adane, Tadele Mulaw, Bruno L. Travi, Rawliegh Howe, Asrat Hailu, Tamrat Abebe, and Peter C. Melby
Journal
Open Forum Infectious Diseases
Abstract
Co-inhibitory receptors (immune checkpoints) regulate activated
immune cells. Their expression on T cells can limit host defense. We
hypothesized that chronic Leishmania donovani infection in patients
with visceral leishmaniasis (VL) leads to expression of co-inhibitory
receptors that could be markers of treatment response and clinical
outcome.