Title
Low levels of DNA repair enzyme NEIL2 May exacerbate inflammation and genomic damage in subjects with stable COPD and during severe exacerbations
Authors
Victor J. Cardenas,Justin B. Seashore,Nisha Tapryal, Moe Ameri,
Rosalinda Rivera, Kabir Sharma, and Tapas Hazra
Journal
Respiratory Research
Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic
inflammatory airway disease that is an independent risk factor for lung
cancer. Reduction in NEIL2 function, a DNA glycosylase involved in
DNA repair during transcription, has been associated with an increased
incidence of malignancies in humans. NEIL2 knockout mouse models
have demonstrated increased inflammation and oxidative DNA damage
in the lungs after exposure to an inflammatory insult, but data are
lacking regarding NEIL2 function in individuals with COPD. We
investigated whether NEIL2 levels and oxidative DNA damage to the
transcribed genome are reduced in individuals with stable COPD and
during severe acute exacerbations of COPD (AECOPD).